Public Safety Advisory: Heightened Threat of Fentanyl Mixed with Emerging Synthetic Drugs - DEA May 12, 2026

DEA issued a national advisory warning that illicit fentanyl is increasingly being mixed with xylazine, nitazenes, medetomidine, cychlorphine, and other synthetic substances. The advisory emphasizes that many of these substances are not reversed by naloxone and may significantly complicate overdose response efforts. This resource could support Tennessee prevention campaigns, treatment provider education, and harm reduction messaging.

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